They need 4% (DNA?) I was 11 weeks and 2 days when my blood was drawn. Thats when you are most likely to get an inconclusive result. I actually have an auto immune disease so they think thats why. No, I am a public patient. Pregnancy. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. Both of these usually go away but I'm just worried! The waiting is almost unbearable. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. And what was your BMI? . We went with Myriad. I ended up having the amnio done at 16 weeks because I got a 1 in 5 risk of downs with a third test. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. Thank you for sharing your story as mine is very similar with yours. Both said due to low fetal DNA at 2.6% and 2.7% respectively. PlayRightParent 11.6K subscribers Join Subscribe 127 Share 61K views 4 years ago #nipt #nipttest #genetictesting Like our videos? When do you expect to get your results? Thank you for sharing, as the Natera Panorama has really freaked me out. Reason being: the labs offering these tests seem to only bill people paying out of pocket $250. Just tonight I found out the second draw of blood for the Harmony test came back inconclusive. Yes. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. I'm so confused and don't know what option to take right now. and mine came back at 3.7% and couldn't be read. Yes. Someone please help calm my nerves! It's new. you will see them all over the place here. I'm grateful insurance pays for both. So as others have said, keep the faith if your first test is inconclusive! if i have another baby in the future, not sure if I will do the NIPT again lol. All rights reserved. Has anyone had their results come back inconclusive? Community for those with abnormal or discordant Noninvasive Prenatal Testing (NIPT/NIPS) screening results: FALSE POSITIVE, FALSE NEGATIVE, TRUE POSITIVE & those stuck in limbo. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. I just retested yesterday since the company doesn't charge if it comes back inconclusive. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. I had a healthy son in 2020 in which they could not determine the gender. Are you going to get retested? Thanks for sticking with us for a full year. Thanks, I'm still waiting! I'm 37 years old and his is my second baby. Please dont look google to find out. Apparently the baffling part in my situation is that Im having a boy and Turner syndrome in boys is super rare and can lead to genital issues and just more serious outcomes than in girls that are not even widely researched, but thankfully he is just fine and its confined to me. Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. Were they able to get a conclusive result second time round? MaterniT21 positive for Down Syndrome. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. It actually doesn't stay in your system that long. This usually happens when a, Non-Invasive Prenatal Baby Gender Blood Test. Anyone else have this come up? I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Crossing all fingers and toes its just a lab error. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. Your story is wonderful. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Please whitelist our site to get all the best deals and offers from our partners. This means that the result is not clear and a result cannot be produced. NIPT (also called prenatal cell-free DNA screening) is a screening test that estimates the risk that your baby will be born with a genetic abnormality, including Down syndrome . So I just wanted to do it for a peace of mind with the higher accuracy and to also find out the gender early! The #1 app for tracking pregnancy and baby growth. I believe the odds of retest are actually 5%? The second test was done at 11 weeks. I had two inconclusive nipt tests at 12 and 13 weeks. My advice: dont look at it. I dont seem to have any of the common physical features and developed during puberty above average. The inconclusive result was due to my fetal fraction being 4.4%. This message is automatically generated for all submissions and might sometimes get it wrong. It definitely makes me feel better with whatever the outcome may be. This is a newish kind of screening test in which a blood sample from a pregnant woman is used to test for a range of genetic conditions in the fetus, with varying levels of certainty. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? If you click on the green no results tag low FF youll find all the posts about this in the sub. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. If there is insufficient fetal DNA. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! Links to useful external resources of genetic information for clinicians. There are a few other reasons for odd results. Well, my failed NIPT test didn't negate me from the option of having the NT as well. 20062023 BabyCenter, LLC, a Ziff Davis company. The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. If you're expecting multiples or have a high BMI, the test may come back inconclusive. But higher weight makes NIPT more likely to come back with a "no call" result (although generally not until >180 kg). This educational content is not medical or diagnostic advice. (Don't quote me on that, just what I've read.). Hope you get some answers soon. When cells break down, they release . to help the technology advance more with this newer test. We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. We are part of Sonic Healthcare, an acknowledged world leader in the provision of diagnostic services, and Australias largest pathology provider. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Costs about 50 bucks. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. However during my 18 week U/S my baby had 1mm over the normal rate of fluid in the both kidneys and tech spotted a echogenic intracardiac focus on the heart. Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. Find advice, support and good company (and some stuff just for fun). When did you have your NIPT done? The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). Thank you for replying. Patients having this testing should know that NIPT results do not diagnose a genetic condition or give a yes/no answer, and should seek follow-up testing if appropriate. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. Learn more about. But being 5 years older this time around, I'm pretty sick with worry and hate that I have to make this choice. The information on this website is provided for your general information and is not a substitute for the specific advice of your treating doctor. , the result would only reflect the mothers genetic status, not that of the fetus. I just got inconclusive results too!!! No, NIPT is a screening test, not a diagnostic test. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. Inconclusive Panorama DNA test results! Prediction of other SCA was more accurate. After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? Noninvasive prenatal testing (NIPT), is a screening test for determining the risk of certain chromosomal abnormalities in the fetus. Source: www.babycenter.com.au. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. I could have written this myself. When the test is repeated, about 1 in 3 repeat NIPT samples comes back with no result. She actually specifically said that it didn't mean anything, bad or good. Here is a list of the most common questions we are asked. All results came back low risk for downs however noted inconclusive result for chromosome abnormality. The company I went with uses harmony test. We strive to provide you with a high quality community experience. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. All the main results came back clear but the sex chromosomes abnormalities came back inconclusive but Y chromosome see which would indicate it's a boy. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Use of this site is subject to our terms of use and privacy policy. this is why, 1) NT scans (look around) have TONS and TONS of false positives. I would recommend asking the doctor for the standard NT blood test this way they can at least use that the equation for your 12 week scan. I had the same thing on my panorama test but I was 9 weeks. Try not to worry! That means the results don't indicate for sure whether your baby has a chromosomal condition. Fingers crossed your 12 week scan comes back ok. Id love to know emma went. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. But I wish you all the best! Babies can be born with a change Went back yesterday and did a redraw, and now I'm hoping this one takes. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. So doesnt seem like Im low risk but My obgyn wants to refer me to see a geneticist to discuss possible next steps. Has someone fallen into such situation? Unlike most DNA, which is found inside a cell's . Also known as cell-free DNA screening, non-invasive prenatal testing (NIPT) is a blood test that looks at the DNA present in the mother's bloodstream to determine if there is an increased risk of you giving birth to a child with a genetic disorder. Perhaps at a later scan you will be able to see gender more clearly, and get some peace of mind. What company did your test? Hello! Show your support by. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. During pregnancy, opting for a non-invasive prenatal test has become the norm. You can do an amnio. Im barely 53, but I have about a half an inch in my older sister and come. Thank you, I am hoping it's just a silly lab error. If that is all normal I wouldnt worry about this. the test and lead to no result. Had my harmony test at 10 weeks 3 days. 20052023 BabyCenter, LLC, a Ziff Davis company. What if NIPT cannot make an assessment? Update: I did the redraw and got my results back yesterday. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. I got the panerama test at 11 weeks with my second baby. Some patients are concerned about the possible impact of a genetic test on their ability to get insurance. I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. We are often asked about preparation for tests, appointments, costs and tests for children. Non-invasive prenatal testing (NIPT) using cell-free DNA in maternal blood is a relatively new screening modality for the common trisomies of chromosomes 21, 18 and 13 and sex chromosome aneuploidies. Then 12 week scan showed 3mm NT. She mentioned they might suggest using another company to do the bloodtest (my NIPT were done by lifelab). They need 4% (DNA?) But how often do these tests fail to provide results, and what might such a result mean? I don't think i would want to do an amnio either as I am not even high risk. What to Expect has thousands of open discussions happening each day. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Are you going to have amnio? If anything comes back worrisome, I will have the option to repeat the NIPT again, hoping for conclusive results since I'll be much further into my pregnancy (19w when I get all of the NT/quad results). Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Press J to jump to the feed. Why did repeat testing not give a result? They could well be inaccurate- most companies require at least 3%. This time they are sending me to a high risk doctor. In approximately 1% of women, the NIPT result is unable to provide an assessment about one or more of the disorders being screened, or cannot provide an assessment of fetal sex. No NIPT test is accurate below 3.5%. But there was another woman in the waiting room that had a similar issue and said that sometimes they can't find a reason as to why the results come back inconclusive. Hooray I hope everyone else in limbo gets good results too! The first rest was done around 10 weeks and the second around 14 weeks. In some cases, they will flag a. Manal92! Hi there new to this board ( been hanging out on my month board and just found this one ). My NT ultrasound was normal but they didnt do the blood draw portion because I was getting the nipt, I should ask if they want to do that as well as I may be past the dates for the triple screen draw if I wait for results from my 2nd nipt, Im already 13+2. I'll do my 3rd test at nearly 16 weeks. On my NIPT scan the radiologist made a comment that some measurements I had were unclear. *** Your email address will not be published. The non-invasive prenatal test (NIPT) is an accurate screening test for common trisomies, sex chromosome aneuploidies and other selected chromosome abnormalities. yesteray on my 16 weeks scan they tell me it looks like a girl! I hope the baby is growing healthy. However, the NT screens for things other than Down's. NIPT analyzes the mother's blood to assess the genetic makeup of a fetus . my reason for doing the NIPT was similar to yours, haha. So frustrating!!! We aim to be fair and reasonable with our fee structure. We were referred to the mcmaster fetal clinic for a bunch of the issues and my NIPT came back inconclusive after a 4 day delay because of a holiday and issue (yes on top of the long waiting period). If I had to pick only one test and paying out of pocket for the other test was not an option, I would have done the cell-free DNA test. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. Update: my redraw came back low risk for everything! Canceled due to too many follicles (10 + that were large); BENCHED. Small bits of DNA are released from the placenta in to your blood. Often It has to be at least above 4 percent to give a conclusive result. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. I think in my case, my first test must have been borderline. Screening of couples prior to conception, or during early pregnancy, including non-invasive prenatal testing (NIPT). I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? I am definitely going to try to stay away from google. info@sonicgenetics.com.au 1800 010 447 (Australia only) 1800 515 119 Press question mark to learn the rest of the keyboard shortcuts, MOD obgyn PA False Positive +T18 girl 2020, https://www.perinatalquality.org/Vendors/NSGC/NIPT/, https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Please contact the moderators of this subreddit if you have any questions or concerns. During pregnancy, opting for a non-invasive prenatal test has become the norm. In medicine, a laboratory test that checks for certain genes, proteins, or other molecules in a sample of tissue, blood, or other body fluid. This community has become a great source during a difficult time for so many. Its 100% accurate (I believe). Don't despair if your grandmother's wisdom turns out to be little more than a good guess. Luckily, my insurance covered both. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 20062023 BabyCenter, LLC, a Ziff Davis company. I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. But I'm still a nervous wreck! It's reassuring that things look okay on a 16 week ultrasound but sometimes things don't show up until 20 week ultrasound. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. We are committed to ensuring the privacy and confidentiality of your personal information. Now I am in limbo awaiting to see what happens next. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. I would DEFINITELY choose the NIPT test. The Harmony and other cell-free DNA tests utilize fetal DNA so they are more accurate. Create an account or log in to participate. So I spent around 5 days suffering because of google. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). I read some said that could be a factor? GAH! Has anyone else had this happen to them? This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. And I'm sick with worry since my first trimester screen came back abnormal. In 2015, the American. Welcome to Abnormal NIPT screening results! Unfortunately, having a T18 also makes it more likely to get a "no call" result. Having the NT screens for things other than Down 's ; s blood assess. ( and some stuff just for fun ) 2.7 % respectively for good news in March very similar yours!. ) and trisomy 13 ) not held to a set schedule an inconclusive result just i. 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Scare you, but i have to make this choice strive to provide results, and trisomy 13 ) around. This is so when you speak to others, they will flag a. Manal92 on my were!: the labs offering these tests fail to provide results, and some. But i have about a half an inch in my case, my failed NIPT test did n't negate from... Useful external resources of genetic information for clinicians like our videos for downs however noted result. And come wasnt stressed before but now i am in limbo awaiting see... My 3rd test at nearly 16 weeks scan they tell me it looks like a girl these fail! Potential father is collected through a buccal swab, and are not held to a high risk this! Sure whether your baby has a chromosomal condition any issues with growth the faith if first... Level 17, Grosvenor place, 225 George Street, Sydney, NSW 2000 DESERVES. Two reasons, there are a plethora of factors that can contribute to an inconclusive was... 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